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The second instance of Treg control of theimmunological environment was related to their presence at the site of a growing tumorwhere Tregs have the ability to secrete VEGF, which induces angiogenesis and can aid in theescape of tumor cells from the site (Facciabene 2012). Theincrease in cardiac output is believed to be dueto a fall in peripheral vascular resistance fol-lowing hypercapnic acidosis (Cardenas et al.1996). Interactionof selection and mortality with the other factors would also threaten internal validity. Rothman N, Hainaut P, Schulte P, Smith M, Boffetta P, Perera F. CPAP may be weaned byreducing pressure or by reducing the time spent onCPAP each day

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